Doctor Octavius (aka: Doctor Octopus, aka: Doc Oc)
Sam Raimi's take on the troubled mad scientist is somewhat sympathetic. Raimi does a nice job setting up Octavius as a kind-hearted, loving husband and friend dedicated to using his big brain to make the world a better place (after all, with great power comes great responsibility) and then yanking the plugs and destroying the very foundation that was Octavius' identity by killing off everything he ever loved. To make things worse, his very creation meant to do good has now poisoned his conscience and turned him into a global threat. Up to the tender moment of his demise, Octavius' character development (his dip into madness and then redemption) is a roller coaster of emotion that make you feel sorry for his fate (which was ultimately ending up on my list).